Endocrine Abstracts

Subclinical hyperthyroidism (SHyper) is defined as serum FT4 and FT3 levels within their respective reference ranges in the presence of is low or undetectable serum TSH levels. The most common cause of SHyper is exogenous SHyper due to unintentional excessive replacement therapy in hypothyroid patients or to intentional TSH suppressive therapy for malignant thyroid disease. Endogenous SHyper is commonly associated with autonomous thyroid function as occur...

Aim: To address the role of FDG/PET-CT in the follow-up of DTC.Methods: About 110 consecutive patients (86 female, 24 male, mean age 45±13 years), with DTC were selected between 1999 and 2006. All patients underwent total thyroidectomy, radioiodine ablation and had undetectable serum thyroglobulin (Tg) during L-T4 suppressive therapy and negative serum TgAb. The follow-up included a yearly clinical examination with n...

Background: Resistance to thyroid hormone (RTH) is an inherited condition of reduced tissue responsiveness to thyroid hormone (TH), biochemically characterized by elevated serum TH concentrations, with inappropriate, non-suppressed thyrotropin levels (TSH). It is caused by point mutations in the ligand binding domain of the TH receptor (TR) β gene, and the mutant TR interferes with the function of the normal TRs (dominant negative effect). The clinical manifestations of R...